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Anti-aging medical news

Conventional medicine practice follows a disease-based model, where diagnosis and treatment are often instituted when frank disease states are apparent.  Typically, symptoms are managed rather than the cause.
Antaging or preventive medicine is a clinical/medical specialty and field of scientific research aimed at the very early detection, prevention, treatment, and reversal of age-related decline. It is a healthcare model promoting innovative science and research to prolong a healthy lifespan and decrease the incidences of diseases that occur with aging, for example cancer, heart disease, osteoporosis, dementia and diabetes mellitus.
Preventative medicine is well-documented by peer-reviewed medical and scientific journals and employs evidence-based methodologies to conduct patient assessments. Treatments involve natural supplements, vitamins, aminoacids, essential fatty acids, bioidentical hormones, neurotransmitter balancing, nutraceuticals, IV nutrient repletions and many more modalities, including gene therapies, stem cell therapies and nanotechnologies.

Some new concepts in antiaging medicine emerging from the science include:

1.  The safety of bioidentical hormones
The question often asked is how safe are bioidentical hormones when large trials like the women’s health initiative trial have proved that non-exact replica of human hormones may indeed be harmful in the long term.  Bioidentical hormones have been present in the human body for more than 50 million years, so we know that maintenance of health requires bioidentical hormones by the help of Darwinian evolution (1).

Hormones have a wide range of acceptable limits, however a deficiency or excess of a hormone can cause side effects, and they each have typical signs and symptoms (2).  Therefore accurate replenishment with laboratory testing is of paramount importance.

There have been no reported adverse events from bioidentical hormones last year, according to an FDA press conference January 2008 (3).

Do bio-identical hormones cause breast cancer

The answer is no(5).  According to the French cohort study there is no increase in breast cancer in women using bio-identical hormones (4). Avoiding excess environmental estrogen levels, as well as excess estrogen  from any source, may be key to the prevention of breast cancer (6).

Do bioidentical hormones cause heart disease?

The answer is again NO.  A study of CAT calcium scores by Joann E Manson in the June 2007 Jama actually showed less heart disease in the women taking unopposed estrogen (they had hysterectomies and were not given the synthetic progestins (7)

Three articles on the safety of bioidentical hormones :
a) For a good summary and explanation of the issues, see The Cases for Bioidentical hormones Steven F Hotze MD. 2008.(8)
b) The safety of bioidentical hormones-the data vs. the hype by Jacob Teitelbaum, MD from the Townsend letter June 2007 (9)
c) Bioidentical vs Synthetic HRT, A review of the literature by the bioidentical hormone initiative, Erika Schwartz MD, David Brownstein MD, Kent Holtorf MD (10)(11).

2.  The case for resveratrol

Resveratrol, an antiaging phytochemical (grapessed extract) has been and is being studied extensively as a remarkable antiaging nutrient.  The Sinclair resveratrol studies (12) showed that resveratrol  extends the lifespan of diverse species including saccharomyces, caenorhabditis and drosophilia.  Lifespan extension is dependant on Sirtuin 2 (Sir2 ; silent information regulator genes), proposed to underlie the beneficial effects of caloric restriction.  Resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival.  Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, increased mitochondrial number, and improved motor function.      Resveratrol opposed the effects of the high-calorie diet in 144/153 significant altered pathways.  These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and the diseases of aging.
Aging increases cardiovascular mortality by increasing oxidative stress and inflammation.  Resveratrol exerts multifaceted antioxidant and/or anti-inflammatory effects.  Resveratrol was reported to slow aging and increase lifespan in simple organisms and has been suggested as a potential calorie restriction mimetic (13).

3.    Genetic studies

A huge advancement in antiaging accomplishments has been the mapping of the human genome, first announced in 2003.  A lot of medical research is now being done to identify genetic markers of disease that can act as predictors of future onset of disease.     Important to remember is that one’s genetic predisposition is not necessarily one’s destiny.  There is an interaction between the environment (also dietary and lifestyle choices) and the human genome.  The actual “you” or phenotype is the result of this interaction.  The identification of SNPS (single nucleotide polymorphisms), which identify increased risk for certain diseases,  can be overcome with the correct dietary and lifestyle choices, as well as nutraceutical supplementation.

4.     Saliva testing

Saliva is, in effect, the specimen of choice in a variety of the subsets of traditional medical care as well as emerging areas of health measurement and monitoring.  Steroid hormone assessment from saliva allows the specific determination of biologically active, free fractions of the target hormone.  It is the only true reflection of tissue levels of steroid hormones.  Assays for salivary steroid determination must be extremely sensitive as the concentrations of biologically active, free fractions are significantly lower than the concentrations of total analyte in the serum.  The required sensitivity can be achieved with chemiluminescence, or radio-immunoassays.
Any measurement of steroid hormones in serum or plasma will be mainly a reflection of the inactive hormone.  Only a small and indeterminate percentage of the measurement will be the biologically active hormone.  The saliva/plasma ratio of steroid hormones varies from 10:1 (cortisol) up to more than 100:1 (testosterone).  For some hormones such as estradiol, very small concentrations are found in saliva, requiring a highly sensitive method for measurement.  Blood contamination can cause false positive results in some salivary diagnostic applications, and should be taken into consideration when strategizing testing and reporting strategies.

5.    stem cell therapies

Cryogenic preservation of stemcells is a new modality that has emerged in preventative medicine.  After stimulation with GCSF (granulocyte colony stimulating factor), adult stem cells can be collected by aphaeresis and stored for future treatments, like myocardial infarction or for overall immune system reconstitution. This modality is referred to as bio-insurance.
Stem cells have extensive self-renewal ability, multilineage differentiation ability and can rescue a lethally damaged tissue in vivo for the lifetime of the recipient.

Diseases potentially treatable tomorrow with stemcells include :

  • spinal cord injuries
  • stroke
  • severe infectious diseases
  • lou gehrig’s disease
  • breast and ovarian cancer
  • diabetes
  • osteoporosis
  • autoimmune neurological diseases
  • amyloidosis

6.    Neurotransmitter testing

Neurotransmitters are essential chemical messengers that regulate brain, muscle, nerve and organ functions.  The most common neurotransmitters include serotonin, dopamine, norepinephrine, and epinephrine,and gaba.  A low level of these chemicals is common in the general public and is due to lifestyle, environmental, and dietary factors.  People with neurotransmitter deficiencies may suffer from : obesity, depression, anxiety, fibromyalgia, chronic fatigue, insomnia, attention deficit, learning disorders, panic attacks, PMS, migraines, menopausal symptoms, digestive complaints and many more.  The most effective way to correct a neurotransmitter deficiency is to perform a simple urine test to measure the neurotransmitter levels.  The treatment for optimizing the neurotransmitter levels is to provide the basic amino acid precursors or building blocks so the body can replenish the inadequate levels.

References :

1.    http :// _Darwin
Charles Darwin , theory of natural selection
2.    http:// syndrome.html
Transcript of FDA Press conference on FDA Actions on Bio-identical hormones FTS HHS FDA Susan Cruzan January 9,2008-10-20
Climacteric.2002 Dec;5(4):332-40.     Combined hormone replacement therapy and risk of breast cancer in a French cohort study of 3175 women. De Lignieres B et al. French cohort study.
5.   http : //      Causes of breast cancer – the Estrogen controversy, Dixie Mills MD
Breast cancer Book Intro. What your doctor may not tell you about breast cancer by John R.Lee, M.D., David Zava PhD
Estrogen therapy and coronary-artery calcification.     NEJM Volume 356: 2591-2602 June 21,2007 Number 25. JoAnn E. Manson, M.D.,et al
Point/Counterpoint : The Case for Bioidentical Hormones Steven F Hotze Journal of American Physicians and Surgeons Volume 13 Number 2 Summer 2008-10-20
The safety of bioidentical hormones –the data vs. the hype by Jacob Teitelbaum,MD

Bioidentical vs. Synthetic HRt, A review of the literature
11.     Bioidentical hormone
initiative, Erika Schwartz MD, David Brownstein MD, Ken Holtorf MD
12.    Baur et al. Nature.2006 Nov 16;444(7117):337-42.   Resveratrol improves health and survival of mice on a high-calorie diet.
Nature.2006 Nov 16;444(7117)280-1
13.    Labinskyy N et al.   Vascular dysfunction in aging : potential effects of
Resveratrol, an anti-inflammatory phytoestrogen.   Curr Med Chem . 2006 ;13(9)

Last Updated (Thursday, 03 April 2014 12:23)

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