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Does genetic testing help in anyway to predict disease and can one prevent such disease with the correct supplementation and lifestyle change?

Does Genetic Testing Help In Anyway To Predict Disease And Can One Prevent Such Disease With The Correct Supplementation And Lifestyle Change?The integrative medical centre in bryanston also offers genetic testing / SNPS (single nucleotide polymorphisms). These SNPS are a single gene mutation that predispose you to the development of chronic diseases such as cardiovascular disease, osteoporosis, diabetes, obesity, cancer, inability to detoxify, etc. Once these SNPS are identified, with lifestyle change, and the correct supplements for your genetic profile, these SNPS can be overcome.Your genetic profile predisposes you to certain diseases (loading the gun as it were), but it’s incorrect lifestyle, or not the correct supplements that pull the trigger.

The testing is very simple and involves a simple non-invasive cheek swab and you can know your risk status within a few weeks. The good news, is that with the correct personalized nutritional supplement program and lifestyle change these genetic SNPS can be overcome

The integrative medical centre will offer you a tailored nutritional / nutraceutical supplementation advice program depending on the results of the genetic tests

There are the following genetic panels offered at the integrative medical centre :

1. Cardiovascular panel : The following genes are tested (Tumor necrosis factor alpha), Angiotensin converting enzyme, Apolipoprotein C3), Cystathionine B synthetase, cholesterol ester transfer protein, Interleukin -6, lipoprotein lipase, Manganese Superoxide dismutase, MTHFR (Methylene-tetrahydrofolate reductase), Methionine synthase, 5 methylene tetrahydrofolate-homocysteine

Methyltransferase reductase

Cost of panel to determine genetic predisposition to heart disease : R 1250.00

2. bone health / risk for osteoporosis : Tumor necrosis factor, Interleukin-6, vitamin d receptor

Cost of panel to determine risk for osteoporosis : R 1250.00

3. cancer panels :

prostate cancer : a) cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP 17) b) serine/threonine-protein kinase c) oestrogen receptor B (ESR 2), d) glutathione-S-Transferase, e) insulin-like

growth factor 1 (somatomedin C)

colon cancer panel : glutathione-S-Transferase, serine/threonine-protein kinase, caspase-8, p53 suppressor gene

breast cancer : caspase-8, serine/threonine-protein kinase ChK2

Cost of panel to determine risk for cancer : R1850 ( all panels inclusive)

4. Insulin resistance panel : tumor necrosis factor-alpha, angiotensin converting enzyme, Interleukin-6, vitamin D receptor, PPAR-gamma

Cost of insulin resistance panel : R 1250.00

5. Inflammation, antioxidation, detoxification panel : TNF-alpha, MnSOD (manganese superoxide dismutase), Inteleukin-6, Glutathione-S-transferase M1, P1 and T1

Cost of detoxification panel : R 1250.00

It is crucial to know if one has detoxification difficulties due to genetic SNPS. These SNPS can be overcome with the right nutraceutical supplementation

6. Thrombosis / thromboembolism panel : apolipoprotein B, fibrinogen beta chain, factor II, V, VII, hemochromatosis genes, MTHFR (methylenetetrahydrofolate reductase gene), PAI-1 (plasminogen Activator – inhibitor)

Cost of thromboembolism panel : R1450.00

This panel would be indicated for example if one’s family history included the tendency towards thromboembolic disease (for example deep vein thrombosis, pulmonary embolism)

7. Obesity panel : Adiponectin, C1q and collagen domain containing ;Adrenergic receptor B-2 ; Interleukin – 6R (Interleukin 6) ; Agouti-related protein ; Calpain 10 ; fat mass and obesity associated gene ; Guanine nucleotide-binding protein subunit B3 ; interleukin-1B; melanin-concentrating hormone receptor 1 ; PPAR-gamma ; neuropeptide Y

Cost of panel : R 1450.00


Vinpocetine is an extract from the Vinca minor plant. It has a broad range of cognitive enhancing effects. It improves brain circulation and oxygenation; increases brain tolerance to hypoxia and ischaemia; inhibits phosphodiesterase; improves rheological properties of blood, has neuroprotective effects; and it increases glucose transport into the brain. Vinpocetine improves memory, learning ability, cognitive performance, aphasia, dysarthria, agnosia and coordination.

Dosage: 1 tablet twice daily

Stress Damage ControlTM

Contains Rhodiola and Ashwagandha plant extracts which suppress excessive cortisol, released during chronic stress.It is also protective of the hippocampus, against the directly neurotoxic effects of cortisol.

Dosage: 1 capsule (150mg Rhodiola, 100mg Ashwagandha)twice daily

Homocysteine Reducing FormulaTM

Contains folic acid, vitamin B12 and vitamin B6, to reduce homocysteine levels. Homocysteine promotes dementia by cerebral microangiopathy, oxidative stress, apoptosis, enhancement of beta-amyloid neurotoxicity and by NMDA mediated excitotoxicity.

Dosage: 1 capsule daily (supplies 2000mcg folic acid, 1500mcg vitamin B12 [superior methylcobalamin form], 100mg vitamin B6)

Resveratrol (extra strength)

Resvertatrol is polyphenol that protects the brain via Cox-2 and PGE2 inhibition, and by inducing phase II liver metabolism.

Dosage: 1 capsule (100mg) twice daily

N-Acetyl-Cysteine (NAC)

NAC is an amino acid that boosts endogenous glutathione levels, thereby reducing free-radical damage to neurons. NAC also helps reduce homocysteine levels.

Dosage: 1 capsule (500mg) twice daily

Ubiquinol Co-enzyme Q10

Ubiquinol is a superior form of co-enzyme Q10 that helps prevent brain vascular damage. It also is important for optimal neuronal mitochondrial function and minimising thedamage to brain structures caused by reactive oxygen species. The ubiquinol form of co-enzyme Q10 is best because it is 8 times more orally bio-available than conventional co-enzyme Q10 (ubiquinone).

Dosage: 1 capsule (50mg) twice daily

Fish Oil Omega 3 extract

Supplies two omega-3 essential fatty acids known as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). These are important for maintaining brain health and for cell-to-cell communication. SOLAL’s Fish Oil Omega 3 is superior because it is filtered to remove methyl-mercury and other toxins.SOLAL uses the skins and flesh of small fish (anchovies) only, not larger fish (like salmon) which can have a high toxin content and lower omega 3 concentrations.

Dosage: 2-3 capsules(2000-3000mg) after supper.

Alpha Lipoic Acid

Alpha lipoic acid is an anti-glycation nutrient. It therefore helps prevent damage to brain structures that occur in diabetic patients or in patients with insulin resistance or metabolic syndrome.

Dosage: 1 capsule (250mg) once or twice daily.

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