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Osteoarthritis

Also known as: Degenerative Arthritis; Hypertrophic Arthritis; Osteoarthrosis

Description

Osteoarthritis is the most common type of Arthritis. It is characterized by the degeneration, destruction and erosion of the Cartilage in the Joints and bony outgrowths at the edges of the Joints. Articular surfaces become irregular, flattened and poorly adjusted to each other. This causes the Joint Cavity between adjacent Bones to gradually narrow. Eventually Bones may directly scrape against one another. Osteoarthritis is more prevalent in weight-bearing Joints such as those of the knees, hip, ankles, elbows, wrists, spine, and shoulder.

8% to 12% of the population of Western nations are afflicted with Osteoarthritis:
-Approximately 2% of the population of Western nations aged under 45 are afflicted with Osteoarthritis.
-Approximately 30% of the population of Western nations aged between 45 and 60 are afflicted with Osteoarthritis.
-Approximately 63% to 85% of the population of Western nations aged over 65 are afflicted with Osteoarthritis.
-Osteoarthritis occurs most commonly in people aged 40 and over. Excessive Stress or injury can cause Osteoporosis in some people as young as 25.

Osteoarthritis accounts for 27% of the total number of cases of Rheumatic Diseases.
Osteoarthritis is the second leading cause of work disability.

A SIMPLE SOLAL REGIME

SAM-e – One tablet twice a day
Inflammation lowering formula – Two capsules three times a day
Enzymes-Pre-probiotics- Take one capsule three times a day
Pregnenolone- Take one or two capsules daily
CMO – One capsule twice a day

Multi-Mineral – one daily
MSM – one capsule three times a day
Complete – Two capsules daily
Ashwagandha – Two capsules twice a day

These Substances may Alleviate Osteoarthritis

Amino Acids

Supplemental S-Adenosylmethionine (SAMe) may alleviate Osteoarthritis and may help to reverse Osteoarthritis: references
-Supplemental SAMe may enhance the differentiation of Chondrocytes into Chondroblasts (and Chondrocytes).
-Supplemental SAMe may stimulate the production of Cartilage (Cartilage production is sub-optimal in Osteoarthritis patients).
-Supplemental SAMe may improve the structure and function of Cartilage in Joints affected by Osteoarthritis.

Carbohydrates

Chondroitin Sulfate may be a useful treatment for Ostoearthritis: references
-The CSA-C (Chondroitin 6-Sulfate) form of Chondroitin Sulfate inhibits the activity of Elastase, an enzyme that is involved in the degradation of Cartilage that occurs during the progression of Osteoarthritis.
-The CSA-A (Chondroitin 4-Sulfate) form of Chondroitin Sulfate stimulates the synthesis of endogenous Glucosamine by Chondroblasts.

-The optimal strategy for the use of Chondroitin Sulfate for the treatment of Osteoarthritis is a daily dosage of 1,200 mg of a mixture of 60% (i.e. 720 mg) CSA-A + 40% (i.e. 480 mg) of CSA-C.
Glucosamine Sulfate, Glucosamine Hydrochloride and N-Acetyl-Glucosamine (NAG) are presently the natural “treatments of choice” for Osteoarthritis: references
-Glucosamine is an endogenous substance that forms part of the structural backbone of the Glycosaminoglycans that are components of Cartilage - it may repair damaged Joints.
-Glucosamine Sulfate may reduce the Pain and Inflammation associated with Osteoarthritis.
-Beneficial results are usually apparent in Osteoarthritis patients within four weeks of first usage of Glucosamine Sulfate or Glucosamine Hydrochloride and its benefits become increasingly obvious the longer it is supplemented.
-The recommended Glucosamine Sulfate or Glucosamine Hydrochloride dosage for the alleviation/cure of Osteoarthritis is 500 - 1,000 mg three times per day (= 1,500 - 3,000 mg per day).

Electromagnetic Radiation

Exposure to Sunlight may alleviate Osteoarthritis (by stimulating the endogenous manufacture of Vitamin D). [more info]

Enzymes

Supplemental Proteases may minimize the Inflammation and Pain associated with Osteoarthritis: references
-Bromelain (especially when used in combination with other Proteases) may minimize the Pain and Inflammation associated with Osteoarthritis. references
-Chymotrypsin (especially when used in combination with other Proteases) may minimize the Pain and Inflammation associated with Osteoarthritis. references
-Papain (especially when used in combination with other Proteases) may minimize the Pain and Inflammation associated with Osteoarthritis. references
-Trypsin (especially when used in combination with other Proteases) may minimize the Pain and Inflammation associated with Osteoarthritis. references
Exogenous Superoxide Dismutase (SOD) (e.g. Orgotein administered via injection to ensure bioavailability) may alleviate Osteoarthritis. references

Hormones

Human Growth Hormone (when administered under the guidance of a physician, via injection, directly into damaged Joints) may regenerate the Cartilage of damaged Joints by up to 90% (after one application) and may therefore be useful for the treatment of Osteoarthritis. references
Pregnenolone may be of some benefit to Osteoarthritis patients. references

Lipids

Cetyl Myristoleate (CMO) may alleviate the Pain and Inflammation associated with Osteoarthritis. references

Minerals

Boron may alleviate Osteoarthritis (due to its effect on Calcium metabolism). references
Magnesium Bicarbonate (1.5 liters of Magnesium Bicarbonate-containing Water per day for at least six weeks) may cause the remission of Osteoarthritis (by counteracting the Acidosis (acidity) that may cause Osteoarthritis). [more info]
Manganese (30 – 40 mg per day in combination with Glucosamine Hydrochloride and Chondroitin Sulfate) may alleviate Osteoarthritis. references
Molybdenum (400 - 500 micrograms per day) may alleviate many of the symptoms of Osteoarthritis. references
Osteoarthritis may occur as a result of Phosphorus deficiency - Phosphorus may alleviate the symptoms of Osteoarthritis. [more info]
Selenium may prevent and alleviate Osteoarthritis. references

Silicon may facilitate the removal of the arthritic nodules and spurs associated with Osteoarthritis. [more info]
Osteoarthritis patients are often found to be deficient in Sulfur (as measured by the Cystine content of fingernails) - supplemental Sulfur (either orally or via Sulfur baths) may alleviate the Pain associated with Osteoarthritis and may restore endogenous Sulfur levels to normal. references

Pharmaceutical Drugs

Doxycycline may retard the further progression of Osteoarthritis (due to its ability to inhibit the production/activity of Collagenase in Chrondrocytes). references
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly employed in the treatment of Osteoarthritis:
-Caution: although NSAIDs suppress the Pain associated with Osteoarthritis, their prolonged use is associated with an acceleration of the progression of Osteoarthritis and increased Joint destruction. references

Sulfuric Compounds

Methylsulfonylmethane (MSM) (2,250 mg per day) may alleviate Osteoarthritis (by improving the integrity of Cartilage and Joints). references

Vitamins

Folic Acid (6,400 mcg per day combined with 20 mcg of the Cyanocobalamin form of Vitamin B12 per day) may improve the grip strength of Osteoarthritis patients with equal efficacy to NSAIDs. references
The Niacinamide form of Vitamin B3 (3,000 mg per day) may be an effective treatment for Osteoarthritis - Niacinamide therapy may improve the global impact of Osteoarthritis, may improve Joint flexibility, may improve mobility, may reduce Inflammation and may permit Osteoarthritis patients to reduce their dosage of Anti-Inflammatory Drugs. references
Vitamin B5 may alleviate the Joint Pain and Stiffness associated with Osteoarthritis. references
Vitamin B6 may reduce the size and Inflammation of Hebderden’s Nodes in Osteoarthritis patients. references
Vitamin B12 (20 mcg of the Cyanocobalamin form of Vitamin B12 per day combined with 6,400 mcg Folic Acid per day) may improve the grip strength of Osteoarthritis patients with equal efficacy to NSAIDs. references
Vitamin C may retard the erosion of Cartilage that occurs during the course of Osteoarthritis and may increase the synthesis of the endogenous Glycosaminoglycans that are necessary to repair damaged osteoarthritic Joints. references
Vitamin D may help to prevent Osteoarthritis: references

-People with the highest intake of Vitamin D throughout their life have the lowest incidence of Osteoarthritis.
Vitamin E may alleviate the Pain associated with Osteoarthritis (by inhibiting Prostaglandins). references

These Foods/Herbs may Alleviate Osteoarthritis

Animal-Derived Supplements

Bovine Cartilage may alleviate the Pain associated with Osteoarthritis (due to the Glycosaminoglycans and Protein content of Bovine Cartilage). references
Green-Lipped Mussels extract may alleviate Osteoarthritis (due to its anti-inflammatory actions). references
Shark Cartilage may alleviate Osteoarthritis (by stimulating the growth of new Cartilage and by inhibiting the formation of new Blood Vessels where the Osteoarthritis is progressing): references
- Shark Cartilage may alleviate the Pain associated with Osteoarthritis (due to the Glycosaminoglycans and Protein content of Shark Cartilage).
Velvet Deer Antler may be useful for the treatment of Osteoarthritis. references

Herbs

Arnica (gel applied topically) may reduce the severity of Osteoarthritis symptoms. references

Ashwagandha may alleviate the Pain and disability of Osteoarthritis. references
Boswellia (extract) may alleviate the Inflammation associated with Osteoarthritis (however it has no effect on the underlying degeneration of the Joints that occurs during the progression of Osteoarthritis). references
Devil’s Claw may alleviate the Pain and Inflammation associated with Osteoarthritis. references
Ginger may alleviate the Pain and Inflammation associated with Osteoarthritis (by inhibiting the inflammatory eicosanoids that contribute to the Pain and Inflammation associated with Osteoarthritis). references
Green Tea may help to prevent and treat Osteoarthritis. references
Guggulipid may reduce the symptoms of Osteoarthritis. references
Nettle (leaf) may be useful for the treatment of Osteoarthritis (it may reduce levels of Interleukin 1 and Tumor Necrosis Factor, which are strongly implicated in the development and progression of Osteoarthritis when produced in excess). references
Willowbark may alleviate the Pain associated with Osteoarthritis. references

Yucca may reduce the Pain, Inflammation and Joint stiffness associated with Osteoarthritis (due to the Saponins content of Yucca). references

Oils (dietary Oils)

Cod Liver Oil may reduce Pain in Osteoarthritis patients and may improve the ability of Osteoarthritis patients to participate in normal activities. references

Other Factors that may Alleviate Osteoarthritis

Exercise

Regular (light) Exercise (especially Aerobic Exercise) is a recommended treatment for Osteoarthritis. references

These Substances may Exacerbate or Cause Osteoarthritis

Enzymes

Collagenase may be implicated in the destruction of Cartilage that occurs during the progression of Osteoarthritis. references

Elastase may be implicated in the destruction of Cartilage that occurs during the progression of Osteoarthritis. references
Hyaluronidase may be implicated in the destruction of Cartilage that occurs during the progression of Osteoarthritis.
Excessive activity of Phospholipase A2 in Chrondrocytes may contribute to the symptoms of Osteoarthritis. references

Immune System Chemicals

Excessive Interleukin 1 (Interleukin 1b form) may be implicated in the destruction of Cartilage and the Inflammation that occurs during Osteoarthritis. references
Excessive activity of Tumor Necrosis Factor (TNF-a) may stimulate the destruction of and damage to Cartilage that occurs during the progression of Osteoarthritis. references

Minerals

Excessive consumption of Sodium may contribute to Osteoarthritis (by accelerating the loss of Calcium from the Bones).

Neurotransmitters

Osteoarthritis patients often exhibit elevated levels of Substance P in their blood and Synovial Fluid:
-Excessive Substance P may contribute to Osteoarthritis by destroying the Cartilage in Joints.
-Excessive Substance P may be further involved in Osteoarthritis by facilitating the transmission of Nerve Impulses relating to Pain that are an outcome of Osteoarthritis.
Pharmaceutical Drugs

Although Aspirin may produce short-term, symptomatic relief of Osteoarthritis, it may accelerate the progression of the destruction of the Joints in Osteoarthritis patients.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) may accelerate the Joint destruction that is associated with Osteoarthritis. references

These Ailments may Increase the Risk of Osteoarthritis

Aging Process

The incidence of Osteoarthritis may increase with the progression of the Aging Process.

Metabolism

People afflicted with Obesity may have an increased risk of developing Osteoarthritis. references

Osteoarthritis may Cause these Ailments

Musculoskletal System

Some cases of Backache may be caused by Osteoarthritis.
Heberden’s Nodes may occur in Osteoarthritis patients.
Temporomandibular Joint Dysfunction may occur as a clinical manifestation of Osteoarthritis.

 
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